Is Zepbound Better Than Wegovy?

At Dr. Shima Hadidchi Family Practice, we are committed to offering effective, evidence-based solutions for chronic weight management to our patients in the High Desert community. Two of the most promising prescription medications currently available for adults struggling with obesity or excess weight—especially those with additional health concerns—are Zepbound and Wegovy.

Zepbound (Tirzepatide) and Wegovy (Semaglutide) are both weekly injections approved for weight loss, but they work a little differently. Zepbound targets two hormone receptors (GIP and GLP-1), while Wegovy targets only GLP-1. This dual action with Zepbound may lead to greater average weight loss in studies, while Wegovy has been on the market longer with a well-established safety record. Both help reduce appetite, slow digestion, and improve feelings of fullness, but their dosing amounts and escalation schedules differ.

Another difference is in approvals and added benefits. Wegovy is approved for adults and some adolescents and has proven heart-protective effects in people with obesity and cardiovascular disease. Zepbound is approved for adults only and has also shown benefits in conditions like sleep apnea linked with obesity. Side effects for both are similar, mostly involving the digestive system, and the choice often comes down to individual health needs, tolerance, and insurance coverage.

At Dr. Shima Hadidchi Family Practice, weight management is never “one size fits all.” If you are interested in learning more about Zepbound, Wegovy, or other tools for managing your weight and improving your health, Dr. Shima Hadidchi, MD, will work closely with you to develop a holistic plan that may include medication, nutrition, physical activity, and ongoing support.

At Dr. Shima Hadidchi MD Family Practice, we are committed to helping our patients achieve their health goals, including effective and sustainable weight management. Two of the leading medications currently approved for chronic weight management are Zepbound and Wegovy. Understanding the differences between these options can help you make informed choices about your care.

Studies have shown that Zepbound is more effective than Wegovy for weight loss. For example, in one trial, people taking Zepbound lost an average of 20% of their body weight, while those on Wegovy lost an average of 14%.

The difference is in how they work. Both medications are effective, but Zepbound is a dual-action drug that works on two different hormones, not just one. This combined effect is thought to lead to greater weight loss. However, both are considered safe and effective tools for chronic weight management, and the best choice depends on a patient’s individual health profile and goals.

At Dr. Shima Hadidchi MD Family Practice, we carefully evaluate each patient’s medical history, lifestyle, and treatment preferences before recommending a weight management plan. Together, we will find the most suitable approach to help you achieve a healthier weight and improve your overall well-being.

At Dr. Shima Hadidchi Family Practice, we are committed to providing comprehensive care for individuals seeking effective and safe weight management solutions. Two of the most advanced prescription medications approved for chronic weight management are Zepbound and Wegovy. Both are designed for adults with obesity or those who are overweight with at least one weight-related health condition.

Clinical studies show that Zepbound tends to lead to greater weight loss than Wegovy. In a head-to-head trial, people using Zepbound lost about 20% of their body weight over 72 weeks, compared to around 13–15% with Wegovy. On average, this translated to roughly 50 pounds with Zepbound versus about 33 pounds with Wegovy, though results vary depending on starting weight and dose.

It’s important to keep in mind that these numbers reflect averages from clinical trials where patients also received diet and lifestyle support. Not everyone will reach these percentages, as factors like dose tolerance, side effects, and personal health play a role. Both medications can be effective tools for weight loss, but Zepbound may offer somewhat greater reductions in body weight when compared directly to Wegovy.

If you are interested in exploring medical options for weight management, Dr. Shima Hadidchi’s Practice provides comprehensive care focused on creating personalized plans tailored to your health needs. This approach supports safe and effective weight loss while addressing overall well-being.

According to clinical trial data, Zepbound has shown a greater average weight loss for long-term results than Wegovy. However, both medications are designed for and considered effective for chronic weight management. The “better” medication for an individual depends on their personal health, goals, and how they respond to the treatment.

Zepbound, which contains the active ingredient Tirzepatide, is a dual-action medication that targets two key hormone receptors (GIP and GLP-1). This combined effect has been shown in clinical studies to result in an average weight loss of over 20% of a patient’s body weight over 72 weeks. This is a higher average weight loss than that observed with Wegovy, making it a powerful tool for those seeking significant long-term results.

Wegovy, which contains Semaglutide GLP-1, is also a highly effective medication for long-term weight management. Clinical trials have shown that patients using Wegovy can achieve an average weight loss of about 15% of their body weight. Both medications require long-term use alongside a commitment to healthy lifestyle changes to maintain results. A doctor will help determine the best medication for you by considering your health profile, potential side effects, and your specific weight loss goals.

At Dr. Shima Hadidchi Family Practice, we believe that medication should be just one part of a comprehensive weight management plan. Long-term success also depends on healthy lifestyle changes, including proper nutrition and regular physical activity. Our team will work closely with you to develop a plan that fits your goals and medical history. Contact us for more information or schedule an appointment. We have convenient locations to serve you in Apple Valley, CA and Victorville, CA. We serve patients from Apple Valley CA, Victorville CA, Spring Valley Lake CA, Hesperia CA, Baldy Mesa CA, Mountain View Acres CA, Adelanto CA, and surrounding areas.